Our Research
Multiparametric Ex Vivo Evaluation of Parotid Tumors: Feasibility and Preliminary Results (2026)
Authors: Wojciech Domka, Oliver Böhm, Vitaliy Atamaniuk, et al.
Summary: This ex vivo study combines tabletop MRE with relaxometry, diffusion imaging, and fat quantification to differentiate parotid tumors from adjacent tissue and to derive complementary mechanical and microstructural biomarkers for more comprehensive tumor characterization.
NMR Biomed. 2026; 39(9):e70361. doi: 10.1002/nbm.70361
Dependence of Magnetic Resonance Elastography-Derived Stiffness Values on Selected Imaging Parameters (2026)
Authors: Łukasz Hańczyk, Marzanna Obrzut, Marian Cholewa, Vitaliy Atamaniuk
Summary: This prospective human and phantom study demonstrates that liver MRE-derived stiffness is systematically affected by driver power and slice thickness, emphasizing the importance of protocol standardization for reliable stiffness measurements.
Magn. Reson. Med. 2026; doi: 10.1002/mrm.70391
Magnetic Resonance Elastography for Noninvasive Evaluation of Parotid Tumors: A Feasibility Study (2026)
Authors: Vitaliy Atamaniuk, Marzanna Obrzut, Łukasz Hańczyk, et al.
Summary: This feasibility study shows that parotid MRE using a custom bilateral facial driver can noninvasively quantify tumor stiffness, revealing stiffness differences between tumor types and healthy gland while highlighting overlap that limits standalone diagnostic accuracy.
Eur. J. Radiol. 2026; doi: 10.1016/j.ejrad.2026.112970
Toward Self-Contained Cardiac Magnetic Resonance Elastography: Deep Learning-Based Segmentation of the Left Ventricular Myocardium (2026)
Authors: Vitaliy Atamaniuk, et al.
Summary: This work demonstrates that nnU-Net and MedSAM can segment the left ventricular myocardium directly from native cardiac MRE at inter-reader-level accuracy, supporting a move toward a fully self-contained cardiac MRE postprocessing workflow.
Magn. Reson. Imaging 2026; doi: 10.1016/j.mri.2026.110768
Evaluation of tissue stiffness: A deeper insight into the nature of uterine leiomyomas and its possible clinical applications (2026)
Authors: Bogdan Obrzut, Vitaliy Atamaniuk, et al.
Summary: This review analyzes current evidence on ultrasound and MR elastography for assessing tissue stiffness in uterine leiomyomas, highlighting their ability to characterize viscoelastic properties beyond conventional imaging. The authors discuss the potential clinical value of elastography in improving differential diagnosis and guiding personalized treatment strategies for uterine tumors.
Int. J. Gynecol. Obstet. 2026. doi: 10.1002/ijgo.70809
Free-breathing hepatic 2D magnetic resonance elastography (2025)
Authors: Jiahui Li, Marzanna Obrzut, et al.
Summary: This study demonstrated that rapid, free-breathing 2D MR elastography provides liver stiffness measurements with repeatability and accuracy comparable to conventional breath-hold MRE at 1.5 T. The technique showed strong agreement with standard MRE and offers a reliable, more comfortable alternative for patients unable to perform breath-holds.
Magnetic Resonance in Medicine. 2025; doi: 10.1002/mrm.30483
High-frequency shear wave MR elastography of parotid glands: custom driver design and preliminary results (2024)
Authors: Vitaliy Atamaniuk, Jun Chen, Marzanna Obrzut, et al.
Summary: This study introduces a novel face-adapted passive driver enabling high-frequency MR elastography of the parotid glands, addressing wave attenuation challenges in small superficial organs. The preliminary results demonstrate the feasibility of high-resolution stiffness mapping of parotid tissue, supporting the potential of MRE for improved quantitative assessment of salivary gland pathology.
Scientific Reports. 2024; 14. doi: 10.1038/s41598-024-75806-2
3D vector MR elastography applications in small organs (2024)
Authors: Vitaliy Atamaniuk, Łukasz Hańczyk, et al.
Summary: This review outlines the technical principles of 3D vector MR elastography and highlights its advantages over conventional 2D MRE for assessing small organs where complex wave propagation occurs. The paper summarizes emerging clinical applications in organs such as the uterus, pancreas, thyroid, prostate, and salivary glands, emphasizing the untapped potential of 3D vector MRE in quantitative tissue characterization.
Magnetic Resonance Imaging. 2024; doi: 10.1016/j.mri.2024.06.005
Postprandial splenic stiffness changes on magnetic resonance elastography in a young healthy population (2023)
Authors: Marzanna Obrzut, Vitaliy Atamaniuk, et al.
Summary: This prospective study showed that food intake causes a significant increase in spleen stiffness measured by MRE in healthy young adults, with a mean rise of ~8% observed 30 minutes after a meal and persisting for up to 2.5 hours. The results support routine fasting prior to spleen MRE to avoid postprandial bias in stiffness assessment.
NMR in Biomedicine. 2023; 37(2). doi: 10.1002/nbm.5047
Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography (2023)
Authors: Marzanna Obrzut, Vitaliy Atamaniuk, et al.
Summary: This study established normative spleen stiffness values in 100 healthy young adults using 1.5 T MRE, reporting a mean stiffness of 5.09 ± 0.65 kPa. Splenic stiffness showed no significant sex-related differences and did not correlate with liver stiffness or fat content, providing a reference framework for future studies of portal hypertension and related pathologies.
Diagnostics. 2023; 13(17):2738. doi: 10.3390/diagnostics13172738
Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers (2021)
Authors: Marzanna Obrzut, Vitaliy Atamaniuk, et al.
Summary: This study demonstrated that food intake significantly increases liver stiffness measured by MRE in healthy volunteers, with a mean postprandial rise of ~18% (0.40 kPa) observed 30 minutes after a meal and persisting for over 2 hours. The findings highlight the importance of fasting for at least 3–4 hours before MRE to avoid overestimation of liver fibrosis.
Scientific Reports. 2021; 11:19786. doi: 10.1038/s41598-021-99243-7
Magnetic resonance elastography of a uterine fibroid with massive lymphocytic infiltration — an extremely rare finding (2020)
Authors: Bogdan Obrzut, Marzanna Obrzut, et al.
Summary: This case report presents the first MRE assessment of a uterine leiomyoma with massive lymphocytic infiltration, an extremely rare histopathological finding. Despite features that could mimic malignancy, the mechanical properties of the tumor differed from those of typical uterine sarcomas and fibrotic leiomyomas.
Ginekologia Polska. 2020; 91(3):174. doi: 10.5603/GP.2020.0034
Value of liver iron concentration in healthy volunteers assessed by MRI (2020)
Authors: Marzanna Obrzut, Vitaliy Atamaniuk, et al.
Summary: This study established normative liver R2* values in 100 healthy young adults (mean age 22.9 years) using 1.5 T MRI with the IDEAL-IQ technique, finding a mean R2* of 28.72 s⁻¹ (range 23.67–37.77 s⁻¹). The results indicate that in the absence of fibrosis or steatosis, liver stiffness and fat fraction do not correlate with R2*, supporting its use as a noninvasive reference for assessing liver iron concentration.
Scientific Reports. 2020; 10:17887. doi: 10.1038/s41598-020-74968-z
Uterine leiomyomas: correlation between histologic composition and stiffness via MRE — a Pilot Study (2020)
Authors: Marzanna Obrzut, Bogdan Obrzut, et al.
Summary: Pilot clinical study using MRE to measure stiffness of uterine fibroids in 12 patients. Demonstrated that fibroid stiffness correlates with histological extracellular matrix content, supporting MRE’s potential for non-invasive tissue characterization.
Ginekologia Polska. 2020; 91: 373-378. doi: 10.5603/GP.a2020.0067
Normative values for magnetic resonance elastography–based liver stiffness in a healthy population (2019)
Authors: Marzanna Obrzut, Vitaliy Atamaniuk, Bogdan Obrzut, et al.
Summary: In this paper, we established baseline liver stiffness values via MRE in 102 healthy volunteers (mean 2.14 kPa), showing no significant influence of sex, BMI, or fat content. This dataset supports future liver fibrosis diagnostics.
Pol Arch Intern Med. 2019; 129: 321-326. doi: 10.20452/pamw.4456